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Bob suffers from mysterious open-wound sores all over his body. Virginia can't wait to have her lump removed. Tom is desperate to find a cure for his itchy skin.

Steven's bump is so large, his daughter thinks he is growing a monster on his back. Ethan suffers from an irritating rash in an awkward place on his body.

John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps on her arms, chest, and belly.

Cystem Shutdown! Gerard has nearly a hundred lumps varying in size all over his body. Eric has a large bump on his head that he calls his 'on/off button.

Traci's confidence was destroyed after years of bullying about the bumps that have plagued her face for 20 years. Ravon has a unique dangling growth on his leg.

Chloe is dress shopping with her mum, but worries her voice won't be heard. And, Diane has waited 25 years to go dress shopping for her wedding to Kathy.

Since meeting at a bariatric rehab centre in 2006, Lee and Rena's weight has skyrocketed. The couple now makes a second attempt to save their lives.

Marianna has lost 5 stone for her wedding, yet still lacks confidence about her appearance. Jo and Al find a solution to make her feel amazing on the big day.

Helen never wears dresses and is anxious about choosing the right gown. And, Jo and Alison manage a last-minute refit for bride Aimee after surprise weight loss.

Third-time bride Janine hopes to finally find a gown with a wow factor but will her mum approve? Jacqui worries that her chosen dress can't contain a baby-bump.

After being released from the psychiatric hospital, Dr. Sturgis unexpectedly breaks up with Meemaw.

A Parasol And A Hell Of An Arm. A church carnival leads Missy to try out for the baseball team. Meanwhile, Meemaw struggles after her breakup with Dr. Sturgis.

Sheldon starts the first internet flame war, and Meemaw is unhappy when George spends time with her new boyfriend.

The university tries to recruit Sheldon, through George. Georgie gets a job working for Meemaw's new boyfriend. Mary decides to rid her home of greed.

Mary gets Pastor Jeff involved when Sheldon isn't invited to Billy's birthday party. George, meanwhile, has 'male-bonding time' with Dr. Sturgis.

Sheldon fakes being sick to avoid a swim test at school. Meanwhile, Dr. Sturgis spies on Meemaw's new boyfriend.

Georgie and Fagenbacher go head-to-head when Fagenbacher tries to sabotage Georgie's attempt to honour his dad.

Georgie's plan to get on the news sparks a feud between Mandy and a rival weathergirl. Meanwhile, Mandy tries to use the conflict to help her career.

Penny seeks Sheldon's help to better comprehend Leonard's physics work. Wolowitz sees green when Leonard invites Bernadette to watch an experiment.

A Christmas visit from his mother has Leonard discovering she's kept a lot of news from him that she shares with Sheldon.

Leonard is aghast to find out that Penny believes in psychics. Sheldon tries to assist Koothrappali in picking up a girl at a university party.

A robbery of their apartment sees Leonard and Sheldon call on their friends to devise a security system.

Stuck on the solution to a physics problem, Sheldon tries different methods to change his thinking, including working at The Cheesecake Factory.

When Leonard is offered a trip to Switzerland on Valentine's Day to see a particle accelerator, he must choose between taking Penny or Sheldon.

An appearance in traffic court comes at the worst possible time for Sheldon, the same day Stan Lee is appearing at the comic book store.

The guys go to a garage sale and find a ring from the Lord of the Rings films, and the rare find threatens their friendship.

Sheldon's fear of speaking in front of large groups threatens his ability to accept an award, so the gang tries to help him prepare for the big night.

Sheldon squares off at the bowling alley against nemesis Wil Wheaton. Leonard's miffed over Penny's response when he says, 'I love you.

Following Leonard and Penny's break up, Sheldon tries to hide from Leonard and the gang that he had a friendly spaghetti dinner at Penny's.

Sheldon hosts a visiting female physicist, but her intelligence seems matched by her libido.

A squabble over the thermostat setting leads to Leonard going over to Penny's and recounting the story of how he met and moved in with Sheldon.

Howard and Raj set Sheldon up on an Internet dating site. Penny discovers that she can't go back to dating dumb jocks after dating Leonard.

Howard uses a robotic arm for his own pleasure. Sheldon goes on a date with Amy Farrah Fowler, and Penny finds herself accompanying them.

Sheldon calculates that he'll be dead before technology exists to download his consciousness into a robot, so he goes on a healthy-living binge.

Sheldon breaks up with Amy Farrah Fowler, and the guys worry when he starts replacing her with cats.

Wolowitz is embarrassed when a secret of his is revealed, and Sheldon and Raj battle at work.

Sheldon meets Amy's mum and comes to the realisation he no longer wants to see Amy, and Leonard realises everyone is in a relationship except for him.

When Raj's sister has a one-day layover, he forbids the others from hooking up with her, unaware she and Leonard already did long ago.

Ed Gamble hosts captains and Richard Ayoade and Joanne McNally defend wild views. Phil Wang wants Britain run by Chinese people.

Dara Ó Briain makes sense of world events - kind of - with guests Rhys James, Angela Barnes, Neil Delamere, Ed Byrne, Finlay Christie and Zoe Lyons.

Ed Gamble hosts captains and Richard Ayoade and Joanne McNally defend wild views. Phil Wang wants Britain run by Chinese people.

George and Meemaw struggle to manage the Cooper household while Mary plans Pastor Jeff's wedding.

David is back to see Dr. Lee after she spotted a suspicious growth under his eye. And, Alan has a growth on his bicep but is terrified of doctors.

Tim has a massive growth on his back that affects his ability to work and socialise. Meanwhile, a mother-daughter duo has bonded over their bumps.

Janine's extreme obesity has left her nearly immobile. She must overcome her physical and emotional pain if she's ever going to live a normal life.

Narina fears she may have gained weight for her final fitting. Bride Leah's outspoken mum shocks Jo and Al, and there's a strange request for latex.

Pippa returns for her final fitting and is anxious about walking down the aisle. On the big day, Jo and Al arrive to find both bride and groom in meltdown.

Since Rebecca's first visit, Rebecca has lost 21-lbs and her dress no longer fits! Plus, it's an emotional fitting for cancer-survivor Natalie.

Frankie tasks Mike into having a talk with Brick to discuss dating etiquette. Sue tries to work up the courage to tell Sean her feelings for him.

Axl gets sick and tired of having Mike tell him how to run his life. Frankie swears that she's seeing something mysterious flying through the house.

Frankie forces Brick to ask Cindy to the prom. Lexie talks a clueless Axl into giving Sue a belated 21st birthday present.

Mary gets Pastor Jeff involved when Sheldon isn't invited to Billy's birthday party. George, meanwhile, has 'male-bonding time' with Dr. Sturgis.

Sheldon fakes being sick to avoid a swim test at school. Meanwhile, Dr. Sturgis spies on Meemaw's new boyfriend.

George and Meemaw struggle to manage the Cooper household while Mary plans Pastor Jeff's wedding.

A squabble over the thermostat setting leads to Leonard going over to Penny's and recounting the story of how he met and moved in with Sheldon.

Howard and Raj set Sheldon up on an Internet dating site. Penny discovers that she can't go back to dating dumb jocks after dating Leonard.

Howard uses a robotic arm for his own pleasure. Sheldon goes on a date with Amy Farrah Fowler, and Penny finds herself accompanying them.

Sheldon calculates that he'll be dead before technology exists to download his consciousness into a robot, so he goes on a healthy-living binge.

Sheldon breaks up with Amy Farrah Fowler, and the guys worry when he starts replacing her with cats.

Wolowitz is embarrassed when a secret of his is revealed, and Sheldon and Raj battle at work.

Sheldon meets Amy's mum and comes to the realisation he no longer wants to see Amy, and Leonard realises everyone is in a relationship except for him.

When Raj's sister has a one-day layover, he forbids the others from hooking up with her, unaware she and Leonard already did long ago.

Sue and Brick enter a trivia contest for a trip for two to London for the upcoming Royal Wedding. Axl is offered a life-changing job interview.

Frankie tries to stop Axl from moving to Denver for a job. Sue is depressed over Sean leaving for Ghana without ever telling him how she feels.

A Heck Of A Ride Part 1. Axl leaves the nest as the family takes a road trip to Denver, where he will start his new job and a new life away from home.

Sheldon catches a struggling Paige shoplifting. Meanwhile, George Sr. is furious when Georgie tries to buy his way out of chores.

George and Georgie go camping with Meemaw's new boyfriend, Dale, but things get complicated when her ex-boyfriend tags along.

Sheldon and Georgie bond over a money-making opportunity. Meanwhile, Mary is concerned when Missy misuses religion.

The rest of the gang is interviewed by the FBI for Wolowitz's security clearance, with Sheldon accidentally letting slip some damaging information.

The guys camp out to see a print of Raiders of the Lost Ark with 21 extra seconds and are outraged to see Wil Wheaton and his friends skip the line.

Penny asks Leonard to lie to her visiting father, while Howard, Raj and Bernadette spend all night looking through a telescope.

Amy crushes on one of Penny's dim ex-boyfriends, Zack. Raj and Wolowitz argue over who'd be the better superhero.

The guys get Zack and Penny to join their Justice League costume for a New Year's Eve bash at the comic book store.

Their friendship becomes strained when Sheldon tries to take over Leonard's creation of a smartphone application that solves differential equations.

Howard is jealous when Bernadette runs into her old boyfriend at a science event they're attending.

Sheldon wants acting lessons from Penny, hoping they will make him a better teacher.

Ed Gamble hosts captains and Richard Ayoade and Joanne McNally defend wild views. Phil Wang wants Britain run by Chinese people.

Tightly wound Detective David Starsky is forced to partner with easy-going Detective Ken Hutchinson to solve a high-stakes narcotics case.

Sue and Brick enter a trivia contest for a trip for two to London for the upcoming Royal Wedding. Axl is offered a life-changing job interview.

Frankie tries to stop Axl from moving to Denver for a job. Sue is depressed over Sean leaving for Ghana without ever telling him how she feels.

A Heck Of A Ride Part 1. Axl leaves the nest as the family takes a road trip to Denver, where he will start his new job and a new life away from home.

Inoke has a huge and potentially life-threatening bulge on his shoulder. Delano returns to see Dr. Lee and Reed has hundreds of bumps all over his chest.

A devoted girlfriend, Alicia is all smiles on the outside. But inside, she is terrified her addiction to food will kill her before she can marry.

Charlene returns for her fitting but will her out-spoken mum approve of the dress? Heidi goes for a non-traditional gown but her entourage aren't convinced.

Bride Sally is a self-proclaimed 'emotional wreck', who is in desperate need of Jo and Al's help. They head off to the wedding to support her.

Jo and Al reunite with bride Joanna and her feisty dad at her final dress fitting. And, Kimberley's love of 'Beauty and the Beast' extends to a tattoo.

Sue and Brick enter a trivia contest for a trip for two to London for the upcoming Royal Wedding. Axl is offered a life-changing job interview.

Frankie tries to stop Axl from moving to Denver for a job. Sue is depressed over Sean leaving for Ghana without ever telling him how she feels.

A Heck Of A Ride Part 1. Axl leaves the nest as the family takes a road trip to Denver, where he will start his new job and a new life away from home.

Sheldon catches a struggling Paige shoplifting. Meanwhile, George Sr. is furious when Georgie tries to buy his way out of chores.

George and Georgie go camping with Meemaw's new boyfriend, Dale, but things get complicated when her ex-boyfriend tags along.

Sheldon and Georgie bond over a money-making opportunity. Meanwhile, Mary is concerned when Missy misuses religion.

The rest of the gang is interviewed by the FBI for Wolowitz's security clearance, with Sheldon accidentally letting slip some damaging information.

The guys camp out to see a print of Raiders of the Lost Ark with 21 extra seconds and are outraged to see Wil Wheaton and his friends skip the line.

Penny asks Leonard to lie to her visiting father, while Howard, Raj and Bernadette spend all night looking through a telescope.

Amy crushes on one of Penny's dim ex-boyfriends, Zack. Raj and Wolowitz argue over who'd be the better superhero.

The guys get Zack and Penny to join their Justice League costume for a New Year's Eve bash at the comic book store.

Their friendship becomes strained when Sheldon tries to take over Leonard's creation of a smartphone application that solves differential equations.

Howard is jealous when Bernadette runs into her old boyfriend at a science event they're attending.

Sheldon wants acting lessons from Penny, hoping they will make him a better teacher.

A Heck Of A Ride Part 2. Axl leaves the nest as the family takes a road trip to Denver, where he will start his new job and a new life away from home.

Frankie is struggling in her career, Sue has auditioned for show choir, and Brick wants Frankie to dress as a superhero for his class presentation.

Frankie tries to save her job by organising a publicity stunt involving a car filled with jellybeans. Sue fails swim team try-outs.

Meemaw meets Dale's ex-wife, while Sheldon is forced to work on a group project with reluctant college students.

Sheldon visits CalTech for the first time. Meanwhile, Georgie is furious when Mary listens in on a phone call with his girlfriend.

Sheldon accuses Dr. Sturgis of plagiarism. Georgie has an awkward run-in with Veronica while on a date with his new girlfriend, Jana.

After meeting at a fundraising gala, an aged but wealthy Caltech donor makes Leonard ponder if he's willing to have sex with her to secure a donation.

Howard contemplates a serious decision in his relationship with Bernadette, and Leonard and Raj's sister start seeing each other again.

Sheldon is in a crisis when he realises he's not the epicentre of the group, so he decides to find new friends.

Leonard has a tough choice to make when Priya asks him to stop spending time with Penny, and Howard keeps pestering Sheldon with a magic trick.

The guys become sleuths to find out who hacked Sheldon's online-game account.

Sheldon and Amy decide to start rumours about themselves as a social test. Howard takes his relationship with Bernadette to an even higher level.

Priya uses her legal expertise to rip apart Sheldon's roommate agreement, and the women take the flustered Sheldon out dancing.

Raj makes an attempt to cure his phobia of talking to women, and Penny spies on Leonard and Priya with the help of Bernadette.

Amy steps into the spotlight in more ways than one. Andrea shares a surprising health update with Tammy. The older siblings draw a line in the sand.

Jaz and Nesha set out to make their Cabo dream a reality, but trip planning brings major challenges. Jaz navigates the realities of accessible travel.

With pandemic safety protocols in place, Dr. Lee reopens her office. Patients include Monica, who has a large birthmark growing on the side of her face.

A Heck Of A Ride Part 2. Axl leaves the nest as the family takes a road trip to Denver, where he will start his new job and a new life away from home.

Frankie is struggling in her career, Sue has auditioned for show choir, and Brick wants Frankie to dress as a superhero for his class presentation.

Frankie tries to save her job by organising a publicity stunt involving a car filled with jellybeans. Sue fails swim team try-outs.

Dr. Lee treats Reginald, who has a rare growth on the back of his head. Che'Re has a prominent bump on her face, and Juan has painful boils on his neck.

Liz is bed-bound with severe lymphedema making it impossible to walk. She's isolated and lives with her mum who is too ill to care for her.

Bride Marta's mum and sister have flown in from Spain to see the final fitting. But after breaking her ankle, can Jo and Al help Marta on her big day.

Tucked away in rural Essex is a boutique dedicated to curvy brides. Jo Cooke and Alison Law offer big brides-to-be the chance to look and feel amazing.

Tanya and fiancée Zsyzsanna break tradition by helping each other find their dresses. Plus, Jo's friend Jade visits the boutique for an important fitting.

A Heck Of A Ride Part 2. Axl leaves the nest as the family takes a road trip to Denver, where he will start his new job and a new life away from home.

Frankie is struggling in her career, Sue has auditioned for show choir, and Brick wants Frankie to dress as a superhero for his class presentation.

Frankie tries to save her job by organising a publicity stunt involving a car filled with jellybeans. Sue fails swim team try-outs.

Meemaw meets Dale's ex-wife, while Sheldon is forced to work on a group project with reluctant college students.

Sheldon visits CalTech for the first time. Meanwhile, Georgie is furious when Mary listens in on a phone call with his girlfriend.

Sheldon accuses Dr. Sturgis of plagiarism. Georgie has an awkward run-in with Veronica while on a date with his new girlfriend, Jana.

After meeting at a fundraising gala, an aged but wealthy Caltech donor makes Leonard ponder if he's willing to have sex with her to secure a donation.

Howard contemplates a serious decision in his relationship with Bernadette, and Leonard and Raj's sister start seeing each other again.

Sheldon is in a crisis when he realises he's not the epicentre of the group, so he decides to find new friends.

Leonard has a tough choice to make when Priya asks him to stop spending time with Penny, and Howard keeps pestering Sheldon with a magic trick.

The guys become sleuths to find out who hacked Sheldon's online-game account.

Sheldon and Amy decide to start rumours about themselves as a social test. Howard takes his relationship with Bernadette to an even higher level.

Priya uses her legal expertise to rip apart Sheldon's roommate agreement, and the women take the flustered Sheldon out dancing.

Raj makes an attempt to cure his phobia of talking to women, and Penny spies on Leonard and Priya with the help of Bernadette.

Frankie and Mike's romantic plans for their anniversary are thwarted by a sick Brick, a lovesick Sue, and a learner's permit-toting Axl.

Sue sells a huge amount of sausage and cheese samples for the school but must stand up for herself when the school fails to recognise her achievement.

Brick's teachers tell Frankie and Mike that Brick is socially challenged, so Mike thinks basketball is the answer to help Brick interact with others.

When George Sr. accidentally lands the school librarian in the hospital, the Cooper family look after her. Meemaw gives Georgie relationship advice.

When Sheldon learns the house next door is for sale, he looks for the perfect neighbours. Missy pitches against her boyfriend at the baseball game.

Sheldon has a scientific breakthrough at the dentist. Dale and Meemaw go to the casino. Georgie makes a mistake when he's left in charge of the store.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Penny worries that she's screwed things up permanently with her friends after her night with Raj, while Sheldon takes command of the paintball team.

Leonard and Amy get to know each other better at a co-worker's wedding. Howard and Bernadette spend the weekend with Mrs. Wolowitz.

Raj is upset he's the only one of the four guys who's not in a relationship, so Penny sets out to find the perfect date.

Sheldon and Leonard get invited to a housewarming party at Wil Wheaton's house. Howard gets an out-of-this-world opportunity.

Craving a little motherly love, Sheldon competes with the gang for his mother's attention when she comes to visit.

A cute comic book artist tests Leonard's relationship with Priya, while Sheldon, getting into the Halloween spirit, tries to scare the guys.

The family of conjoined twins, Callie and Carter, must decide whether to separate the sisters. Josh shares his life as 'The Tourette's Barber'.

After contracting bacterial meningitis at 15, Paralympian Veronica shares her scars with the world in the hope of inspiring body confidence.

Dennis has several giant growths on his head. Juan has a rare condition he hopes Dr. Lee will understand. Natalie is covered in hundreds of mysterious dark bumps.